Michel C. Nussenzweig, Zanvil A. Cohn and Ralph M. Steinman Professor and head of the Laboratory of Molecular Immunology, has won the Robert Koch Award. Nussenzweig will share the €, prize, given by the Robert Koch Foundation of Germany, with Alberto Mantovani from Humanitas University for their outstanding achievements in immunology. They will be honored at a formal ceremony in November.
Michel C. Nussenzweig
Based in Berlin, the Robert Koch Foundation is a nonprofit organization that supports medical advancement, primarily in the field of infectious diseases, through the promotion of basic scientific research. Robert Koch, the award’s namesake, was the founder of modern bacteriology, for which he won the Nobel Prize in Physiology or Medicine. From until his retirement in , Koch was head of the Institute for Infectious Diseases in Berlin. The Robert Koch Award is one of Germany’s most prestigious scientific prizes.
Nussenzweig, who is also senior physician at The Rockefeller University Hospital, a Howard Hughes Medical Institute investigator, and director of the Christopher H. Browne Center for Immunology and Immune Diseases, studies molecular aspects of the immune system
Michel Nussenzweig: Antibody hunter
In January, when the escalation of novel coronavirus infections was still just beginning in China, immunologist Michel Nussenzweig realized that the world was facing an unusual situation and it was time for him to act. &#;It was clear that this would be a big problem because of the person-to-person transmission and the speed with which it was spreading,&#; says the researcher, who coordinates the Laboratory of Molecular Immunology at Rockefeller University in New York.
Over the following weeks, Nussenzweig and his team of 50 scientists temporarily put aside the research they had been working on. Instead, they began searching for antibodies (proteins synthesized by the immune system) in the blood of COVID survivors that would be capable of neutralizing the novel coronavirus. To accomplish this, the researchers are counting on small donations of blood from people who had the disease caused by the SARS-CoV-2 virus and were cured. As of the end of March, about 30 volunteers had already donated.
Michel is the son of two Brazilian immunology researchers. His father Victor, and mother Ruth Nussenzweig (–), both studied malaria. Born in São Paul
Children of professors often become professors themselves, how to explain this? Well, It&#;s simple science, as Edinburgh scholars around Ian Deary and Stuart Ritchie established in peer-reviewed research: Academic achievement and even financial income are both genetically inheritable, being directly connected to the IQ which is of course genetically inheritable, best scientific proof being a) English political elites and nobility are all supremely intelligent, and b) kids from low-income families, especially those of immigrants, especially those with dark skin, rarely make it into Oxbridge. Both for good scientific reasons.
In this regard, it is pretty straightforward why surprisingly many professors have a professor Dad, and sometimes also a professor Mum. Sometimes at the same university where their genetically superior and IQ-endowed progeny happens to have studied, or even to take up their own faculty chair. Sometimes it is simply enough to say your last name and admit, yes, so-and-so is indeed my dad, mum or uncle, and all academic doors open as if by magic.
My readers might recall two such examples. The MIT molecular biologist David Sabatini long overshadowed hi
Nussenzweig’s laboratory studies the molecular aspects of the immune system’s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses.
The immune system protects vertebrates from a multitude of pathogens. Two types of immune responses have evolved to accomplish this task: one innate and the other adaptive. Adaptive immune responses are primarily carried out by cells called lymphocytes, which produce a diverse repertoire of immune receptors that recognize almost any antigen. Most of these receptors have relatively low affinity for their antigens and must be refined by somatic hypermutation and class switch recombination, yielding high-affinity antibodies that protect against most pathogens, including HIV Hypermutation and selection occur in specialized micro-anatomic
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